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Jonathan J. Hubbard, Michal Pyzik, Timo Rath, Lisa K. Kozicky, Kine M.K. Sand, Amit K. Gandhi, Algirdas Grevys, Stian Foss, Susan C. Menzies, Jonathan N. Glickman, Edda Fiebiger, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M. Sly, Kristi Baker, Kristi Baker, Richard S. Blumberg, Richard S. Blumberg
FcRn and CD32a form a ternary complex under acidic conditions and act together in determining responses to IgG immune complexes. The human autoimmune disease–associated CD32a-H131 variant more avidly forms this ternary complex, leading to greater FcRn-dependent immune responses to IgG.
Brief Definitive Report
Alexandre Boissonnas, Floriane Louboutin, Marie Laviron, Pierre-Louis Loyher, Elodie Reboussin, Sandrine Barthelemy, Annabelle Réaux-Le Goazigo, Christian S. Lobsiger, Béhazine Combadière, Stéphane Mélik Parsadaniantz, Christophe Combadière
This work describes the spatiotemporal orchestration of recently recruited monocyte-derived and resident macrophages during Wallerian degeneration induced by chronic constriction injury of the sciatic nerve and unveils distinct contribution of these two macrophage subsets in myelin degradation and neurofiber regeneration.
Article
Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl F. Wittig, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Lauren M. Goddard, Aileen A. Ren, N. Adrian Leu, Stephanie Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, Lukas E. Dow, Hideto Watanabe, Markus Schwaninger, Wang Min, Douglas A. Marchuk, Xiangjian Zheng, Issam A. Awad, Mark L. Kahn
CCMs arise due to increased MEKK3-KLF2/4 signaling in brain endothelial cells, but the downstream mechanisms of CCM formation remain unclear. Hong et al. show that expression of the ADAMTS5 protease and proteolytic cleavage of the matrix proteoglycan versican by CCM-deficient endothelial cells contribute to CCM formation.
Article
Antonino Cassotta, Philipp Paparoditis, Roger Geiger, Ramgopal R. Mettu, Samuel J. Landry, Alessia Donati, Marco Benevento, Mathilde Foglierini, David J.M. Lewis, Antonio Lanzavecchia, Federica Sallusto
We explored the nature of the human CD4 T cell immunodominance to influenza H1 hemagglutinin and demonstrate that the naïve repertoire is very broad, while the memory repertoire becomes selected toward peptides with a high likelihood to be processed and presented by dendritic cells.
Article
Ioanna Mosialou, Steven Shikhel, Na Luo, Peristera Ioanna Petropoulou, Konstantinos Panitsas, Brygida Bisikirska, Nyanza J. Rothman, Roxane Tenta, Bertrand Cariou, Matthieu Wargny, Elisabeth Sornay-Rendu, Thomas Nickolas, Mishaela Rubin, Cyrille B. Confavreux, Stavroula Kousteni
LCN2 is an osteoblast-enriched secreted protein that regulates food intake. Here, the authors show that LCN2 is upregulated during obesity and diabetes as a protective mechanism to counteract obesity-induced glucose intolerance by decreasing food intake and promoting adaptive β-cell proliferation.
Article
Johanna Kabbert, Julia Benckert, Tim Rollenske, Thomas C.A. Hitch, Thomas Clavel, Vuk Cerovic, Hedda Wardemann, Oliver Pabst
The authors reveal a mechanism of SIgA–microbiota interaction in the adult human gut. They describe antibodies with a high capacity to bind phylogenetically distant members of the microbiota. Such cross-species reactivity does not correlate with antibody polyreactivity but crucially depends on somatic mutations.
Article
Nicole J. Van Bergen, Syed Mukhtar Ahmed, Felicity Collins, Mark Cowley, Annalisa Vetro, Russell C. Dale, Daniella H. Hock, Christian de Caestecker, Minal Menezes, Sean Massey, Gladys Ho, Tiziana Pisano, Seana Glover, Jovanka Gusman, David A. Stroud, Marcel Dinger, Renzo Guerrini, Ian G. Macara, Ian G. Macara, John Christodoulou, John Christodoulou
Patients with severe developmental delay, dysmorphism, and brain abnormalities were identified as having pathogenic mutations in EXOC2, a critical component of the exocyst complex involved in vesicle trafficking, which caused secretory vesicle transport defects in patient-derived cell lines.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 7,
July 6, 2020
Reviews & Opinions
Viewpoint
Zoi Diamantopoulou, Francesc Castro-Giner, Nicola Aceto
Nicola Aceto and colleagues discuss the opportunities and challenges of circulating tumor cells in translational research and precision medicine.
Insights
Sannula Kesavardhana, Thirumala-Devi Kanneganti
Deciphering ZBP1 activation and its role in sterile or viral-induced cell death.
People & Ideas
Stephanie Houston
Siamon Gordon: A half-century fascination with macrophages

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