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Hemraj B. Dodiya, Holly L. Lutz, Ian Q. Weigle, Priyam Patel, Julia Michalkiewicz, Carlos J. Roman-Santiago, Can Martin Zhang, Yingxia Liang, Abhinav Srinath, Xulun Zhang, Jessica Xia, Monica Olszewski, Xiaoqiong Zhang, Matthew John Schipma, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, Sangram S. Sisodia
Dodiya et al. characterize an APPPS1-21 mouse model of Aβ amyloidosis with an antibiotic-perturbed microbiome. Fecal transplantation approaches and microglial depletion studies are employed to establish the causality between the gut microbiota, microglia, Aβ, and neurodegeneration.
Andreas Patsalos, Laszlo Halasz, Miguel A. Medina-Serpas, Wilhelm K. Berger, Bence Daniel, Petros Tzerpos, Máté Kiss, Gergely Nagy, Cornelius Fischer, Zoltan Simandi, Tamas Varga, Laszlo Nagy
Regenerative inflammation in skeletal muscle drives macrophage specification via a regeneration-promoting program. A growth factor–expressing macrophage population develops, producing GDF-15 under the control of RXR and PPARγ. GDF-15 acts as an autocrine and paracrine factor coordinating myoblast proliferation and myeloid cell invasion and activity.
Mikko T. Huuskonen, Yaoming Wang, Angeliki Maria Nikolakopoulou, Axel Montagne, Zhonghua Dai, Divna Lazic, Abhay P. Sagare, Zhen Zhao, Jose A. Fernandez, John H. Griffin, Berislav V. Zlokovic
3K3A-APC has shown promise in human ischemic stroke. Present data support that 3K3A-APC could very well be the first therapeutic agent at our disposal to prevent and/or treat white matter strokes, a major cause of human disability, including cognitive dysfunction.
Ensong Guo, Rourou Xiao, Yifan Wu, Funian Lu, Chen Liu, Bin Yang, Xi Li, Yu Fu, Zizhuo Wang, Yuan Li, Yuhan Huang, Fuxia Li, Xue Wu, Lixin You, Tianyu Qin, Yiling Lu, Xiaoyuan Huang, Ding Ma, Gordon B. Mills, Chaoyang Sun, Gang Chen
WEE1 inhibition modulates the efficacy of cancer immunotherapy by regulating dsRNA and interferon responses, which increases recruitment of anti-tumor T cells with concurrent PD-L1 elevation. This study provides a rationale for combination strategies between WEE1 inhibitors and anti–PD-L1 therapies.
Tomonori Kaifu, Rikio Yabe, Takumi Maruhashi, Soo-Hyun Chung, Hiroaki Tateno, Noriyuki Fujikado, Jun Hirabayashi, Yoichiro Iwakura
Asialo-biantennary N-glycan is identified as a ligand for the inhibitory C-type lectin receptor DCIR, which is important for the homeostasis of the immune and bone system. The interaction between DCIR and asialo-biantennary N-glycans negatively regulates antigen presentation by DCs and osteoclastogenesis.
Brief Definitive Report
Nouraiz Ahmed, Martin Etzrodt, Philip Dettinger, Tobias Kull, Dirk Loeffler, Philipp S. Hoppe, James S. Chavez, Yang Zhang, Germán Camargo Ortega, Oliver Hilsenbeck, Hideaki Nakajima, Eric M. Pietras, Timm Schroeder
By manipulating and quantifying the dynamics of PU.1 protein expression in live differentiating adult HSPCs in vitro, Ahmed et al. report that PU.1 upregulation is not caused by fast direct autoregulation but occurs as a later consequence of hematopoietic differentiation.
Takahiro Nakajima, Toshio Kanno, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Damon J. Tumes, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
The authors find that lung and skin pathogenic CD4+ T cells express high levels of ACC1. ACC1 controls the inflammatory function of the pathogenic CD4+ T cell population to promote type 2 inflammation in the lung and skin.

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