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Leslie A. Sepaniac, Whitney Martin, Louise A. Dionne, Timothy M. Stearns, Laura G. Reinholdt, Jason Stumpff
Kif18a mutant mice produce micronuclei following segregation of unaligned chromosomes but do not spontaneously form tumors. KIF18A KO cells form stable micronuclear envelopes around lagging chromosomes located near the spindle pole and outside the midzone. These data suggest stable micronuclei may not actively promote tumorigenesis.
Article
Sachin Surve, Simon C. Watkins, Alexander Sorkin
Ras GTPases are key membrane-associated elements of the EGFR-MAPK signaling pathway. Surve et al. demonstrate that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and its tubular shaped protrusions and show that a small pool of surface EGFRs sustain signaling along the RAS-MAPK pathway, whereas internalized EGFRs do not significantly contribute to MAPK activity.
Article
Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura
Chen et al. provide a novel insight on how poly(PR) dipeptides from C9orf72 gene exert cytotoxicity. The alternate distribution of Arg facilitates multivalent protein–protein interactions with proteins harboring acidic motifs and disturbs their functions through entrapment in the phase-separated droplets.
Article
Lawrence G. Welch, Sew-Yeu Peak-Chew, Farida Begum, Tim J. Stevens, Sean Munro
COPI vesicles recycle Golgi resident proteins within the Golgi stack. Welch et al. combine two orthogonal proteomic analyses to identify clients for the COPI adaptors GOLPH3 and GOLPH3L, and show that these adaptors interact with the cytoplasmic tails of enzymes from diverse glycosylation pathways by binding membrane-proximal positively charged residues.
Article
James L. Shen, Tina M. Fortier, Ruoxi Wang, Eric H. Baehrecke
Mitophagy is regulated by multiple interconnected pathways, which remain poorly understood in physiological settings. Shen et al. describe a mechanism of Pink1-dependent mitophagy utilizing Vps13D that acts in parallel to Parkin-mediated mitophagy during development.
Article
Sourabh Bhide, Denisa Gombalova, Gregor Mönke, Johannes Stegmaier, Valentyna Zinchenko, Anna Kreshuk, Julio M. Belmonte, Maria Leptin
This paper shows that adjacent cells with similar genetic capabilities to change their own shape enter a tug of war that determines which cell shrinks and which expands. For a cell to contract, its neighbors must yield, requiring a nonlinear stress–strain response in the mechanism governing its physical properties.
Article
Jörg Isensee, Marianne van Cann, Patrick Despang, Dioneia Araldi, Katharina Moeller, Jonas Petersen, Achim Schmidtko, Jan Matthes, Jon D. Levine, Tim Hucho
Isensee et al. describe a peripheral mechanism by which excitation of nociceptive sensory neurons leads to pain hypersensitivity. Depolarization of nociceptors results in cAMP-independent activation of type II protein kinase A (PKA-II) by calcium influx through CaV1.2 channels, which in turn modulates calcium channel activity.

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Current Issue
Volume 220,
Issue 9,
September 6, 2021
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Ye Tian investigates how mitochondrial stress signaling pathways regulate longevity using C. elegans as a model system.
Spotlight
Claudiu Andrei Cozmescu, Paul Gissen
Cozmescu and Gissen highlight work from Belicova et al., which shows that the hepatocyte apical membrane produces Rab35-dependent extensions important for bile canaliculi formation.
Spotlight
Yeojin Lee, Lei Ding
Lee and Ding highlight work from Hao et al. describing that membrane-bound stem cell factor synergizes with VCAM-1 to induce polarized protrusions that regulate adhesion in hematopoietic stem cells.

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