Ubiquitin modification controls protein stability and cargo trafficking, and in this issue Duncan et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202107114) reveal a unique mechanism through which Rab40b/Cul5-mediated ubiquitylation of Rap2 regulates its activity and recycling to the leading edge to control cell migration and invasion.

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