The estrogen antagonist C1628 maintains sustained hypertrophy of the uterine epithelium and the synthesis of many proteins including peroxidase. C1628 is a progestogen, inducing secretion of the protein by surface epithelial and glandular cells. C1628 is a connective tissue mitogen, inducing DNA synthesis in fibroblasts and the endothelium. C1628 and estrogen share these properties mentioned above. Estrogen, however, induced moderate growth of the mucosa within a 24-h period and massive hyperplasia of the mucosa within a 24-h period thereafter. C1628 alone, or in combination with estradiol, does not have mitogenic effect on the mucosa, and in fact blocks the mitotic response normally induced by estrogen alone.
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Article| March 01 1975
Modulation of uterine morphology and growth by estradiol-17beta and an estrogen antagonist.
Y H Kang
W A Anderson
E R DeSombre
Online ISSN: 1540-8140
Print ISSN: 0021-9525
J Cell Biol (1975) 64 (3): 682–691.
Y H Kang, W A Anderson, E R DeSombre; Modulation of uterine morphology and growth by estradiol-17beta and an estrogen antagonist.. J Cell Biol 1 March 1975; 64 (3): 682–691. doi: https://doi.org/10.1083/jcb.64.3.682
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