Electron microscopic evidence is presented, from mitochondria in whole cells of toad urinary bladder and from isolated rat kidney mitochondria, indicating that the divalent cations calcium, strontium, and barium are accumulated in granules localized in the mitochondrial matrix. This accumulation occurs under conditions in which divalent ions are present in the medium bathing either whole cells or isolated mitochondria. The evidence indicates that the divalent ions are deposited on, or in a pre-existing granule, possibly in exchange for other ions. It suggests a possible role of the intramitochondrial granules in the regulation of the internal ionic environment of the mitochondrion. Certain biochemical and physiological implications of this phenomenon are discussed.
Article|
January 01 1964
ELECTRON MICROSCOPIC OBSERVATIONS ON THE ACCUMULATION OF DIVALENT CATIONS IN INTRAMITOCHONDRIAL GRANULES
Lee D. Peachey
Lee D. Peachey
From the Department of Zoology, Columbia University, New York
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Lee D. Peachey
From the Department of Zoology, Columbia University, New York
Received:
March 26 1963
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright © 1964 by The Rockefeller Institute Press
1964
J Cell Biol (1964) 20 (1): 95–111.
Article history
Received:
March 26 1963
Citation
Lee D. Peachey; ELECTRON MICROSCOPIC OBSERVATIONS ON THE ACCUMULATION OF DIVALENT CATIONS IN INTRAMITOCHONDRIAL GRANULES . J Cell Biol 1 January 1964; 20 (1): 95–111. doi: https://doi.org/10.1083/jcb.20.1.95
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