The liver cells of intact male rats given ethyl-α-p-chlorophenoxyisobutyrate (CPIB) characteristically show a marked increase in microbodies and in catalase activity, while those of intact female rats do not. In castrated males given estradiol benzoate and CPIB the increase in catalase activity and microbody proliferation is abolished, while in castrated females given testosterone propionate and CPIB the livers show a marked increase in microbodies and in catalase activity. No sex difference in microbody and catalase response is apparent in fetal and neonatal rats. Both sexes show a sharp rise in catalase activity on the day of birth, with a rapid decline at 5 days after birth. Thyroidectomy abolishes the hypolipidemic effect of CPIB in rats, but microbody proliferation and increase in catalase activity persists in thyroidectomized male rats, indicating that microbody proliferation can be independent of hypolipidemia. Adrenalectomy does not alter appreciably the microbody-catalase response to CPIB. These experiments demonstrate that (1) in adult rats, hepatic microbody proliferation is dependent to a significant degree upon male sex hormone but is largely independent of thyroid or adrenal gland hormones; (2) hepatic microbody proliferation is independent of the hypolipidemic effect of CPIB; (3) displacement of thyroxine from serum protein may not be sufficient cause for stimulation of microbody formation.
Article|
March 01 1969
MICROBODIES IN EXPERIMENTALLY ALTERED CELLS : II. The Relationship of Microbody Proliferation to Endocrine Glands
Donald Svoboda,
Donald Svoboda
From the Departments of Pathology, Medicine, and Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66103
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Daniel Azarnoff,
Daniel Azarnoff
From the Departments of Pathology, Medicine, and Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66103
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Janardan Reddy
Janardan Reddy
From the Departments of Pathology, Medicine, and Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66103
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Donald Svoboda
From the Departments of Pathology, Medicine, and Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66103
Daniel Azarnoff
From the Departments of Pathology, Medicine, and Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66103
Janardan Reddy
From the Departments of Pathology, Medicine, and Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66103
Received:
September 20 1968
Revision Received:
October 22 1968
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright © 1969 by The Rockefeller University Press.
1969
J Cell Biol (1969) 40 (3): 734–746.
Article history
Received:
September 20 1968
Revision Received:
October 22 1968
Citation
Donald Svoboda, Daniel Azarnoff, Janardan Reddy; MICROBODIES IN EXPERIMENTALLY ALTERED CELLS : II. The Relationship of Microbody Proliferation to Endocrine Glands . J Cell Biol 1 March 1969; 40 (3): 734–746. doi: https://doi.org/10.1083/jcb.40.3.734
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