Crystalline inclusions were found in the nuclear envelope and granular endoplasmic reticulum of spinal cord oligodendroglia of the common guppy (Poecilia reticulata) and the lungfish (Polypterus enlicheri). A considerably increased incidence of these inclusions was noted in guppies with congenital and hereditary (sex-linked, recessive) lordosis. Identical crystalline inclusions were observed in protoplasmic and fibrous astrocytes, ependymal cells, and capillary endothelial cells of the spinal cord of the lordotic fish. The oligodendroglia in these fish also revealed a prominent alteration of the endoplasmic reticulum and Golgi apparatus, with the accumulation of dense (secretion?) granules and large amounts of electron-opaque material in markedly dilated sacs of the endoplasmic reticulum. The authors postulate that this alteration is caused by a genetic defect in the control mechanism governing the elaboration of this material in the lordotic guppy, with subsequent stasis and crystallization of this material.
Article|
June 01 1969
CRYSTALLINE INCLUSIONS IN THE NUCLEAR ENVELOPE AND GRANULAR ENDOPLASMIC RETICULUM OF THE FISH SPINAL CORD
Eugene Marquet,
Eugene Marquet
From the Beth Israel Hospital, and Max Wachstein Research Laboratories, Passaic, New Jersey 07055
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Harold John Sobel
Harold John Sobel
From the Beth Israel Hospital, and Max Wachstein Research Laboratories, Passaic, New Jersey 07055
Search for other works by this author on:
Eugene Marquet
From the Beth Israel Hospital, and Max Wachstein Research Laboratories, Passaic, New Jersey 07055
Harold John Sobel
From the Beth Israel Hospital, and Max Wachstein Research Laboratories, Passaic, New Jersey 07055
Received:
August 09 1968
Revision Received:
December 30 1968
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright © 1969 by The Rockefeller University Press.
1969
J Cell Biol (1969) 41 (3): 774–785.
Article history
Received:
August 09 1968
Revision Received:
December 30 1968
Citation
Eugene Marquet, Harold John Sobel; CRYSTALLINE INCLUSIONS IN THE NUCLEAR ENVELOPE AND GRANULAR ENDOPLASMIC RETICULUM OF THE FISH SPINAL CORD . J Cell Biol 1 June 1969; 41 (3): 774–785. doi: https://doi.org/10.1083/jcb.41.3.774
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