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23 March 2009
On the cover
EGF stimulates the small GTPase KRas (green) to move from the plasma membrane to late endosomes and lysosomes (red). KRas continues to signal from these compartments before being degraded.
See page 863.
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In this Issue
In This Issue
Time (and PPARβ/δ) heals all wounds
Organotypic cultures help to unravel how a transcription factor modulates crosstalk between different layers of the skin.
People & Ideas
Marko Kaksonen: Tracking the inner secrets of endocytosis
Kaksonen is probing the function and regulation of the endocytic machinery in yeast using live-cell microscopy and genetics.
Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability
Daniele Catalucci,Deng-Hong Zhang,Jaime DeSantiago,Franck Aimond,Guillaume Barbara,Jean Chemin,Désiré Bonci,Eckard Picht,Francesca Rusconi,Nancy D. Dalton,Kirk L. Peterson,Sylvain Richard,Donald M. Bers,Joan Heller Brown,Gianluigi Condorelli
EvolutionThe evolution of the cytoskeleton