In This Issue
People & Ideas
Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
3D reconstruction by cryo-EM provides the first structural description of a ribosomal biogenesis factor (Nmd3) in complex with the 60S ribosomal subunit.
The microtubule regulator APC is now shown to also regulate actin filament dynamics through its C-terminal “Basic” domain.
CHC binds specifically to aurora A–phosphorylated TACC3, recruiting it to the spindle during mitosis.
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner
Vinculin localizes to tension-bearing cell–cell junctions to help transmit signals from E-cadherin to the actin cytoskeleton in response to mechanical stress.
Polν and Polθ have specialized functions in immunoglobulin gene rearrangements and only contribute to DNA repair when other homologous recombination–related DNA polymerases are absent.
Depletion of the Nup188–Nup93 nuclear pore complex results in enlarged nuclei due to unrestricted protein import.
CENP-C and CENP-N recognize distinct structural elements of CENP-A nucleosomes, providing a foundation for the assembly of other centromere and kinetochore components.