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Cover Image
Cover Image
On the cover
An artistically rendered image showing that the spindle-organizing protein TACC3 (red) fails to localize to the mitotic spindle (green) in the absence of the clathrin heavy chain, resulting in chromosome (blue) misalignment.
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In This Issue
In Focus
APC: More than a beta (catenin) blocker
Tumor suppressor could stop cancer through its effect on actin cytoskeleton.
People & Ideas
Sean Morrison: A root and branch approach to stem cells
Morrison compares different stem cells to understand the mechanisms that regulate regeneration, cancer, and aging.
Review
Report
Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
3D reconstruction by cryo-EM provides the first structural description of a ribosomal biogenesis factor (Nmd3) in complex with the 60S ribosomal subunit.
Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1
The microtubule regulator APC is now shown to also regulate actin filament dynamics through its C-terminal “Basic” domain.
Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability
CHC binds specifically to aurora A–phosphorylated TACC3, recruiting it to the spindle during mitosis.
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner
Vinculin localizes to tension-bearing cell–cell junctions to help transmit signals from E-cadherin to the actin cytoskeleton in response to mechanical stress.
Article
DNA polymerases ν and θ are required for efficient immunoglobulin V gene diversification in chicken
Polν and Polθ have specialized functions in immunoglobulin gene rearrangements and only contribute to DNA repair when other homologous recombination–related DNA polymerases are absent.
The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex
Depletion of the Nup188–Nup93 nuclear pore complex results in enlarged nuclei due to unrestricted protein import.
Dual recognition of CENP-A nucleosomes is required for centromere assembly
CENP-C and CENP-N recognize distinct structural elements of CENP-A nucleosomes, providing a foundation for the assembly of other centromere and kinetochore components.
Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
mTOR induces MyoD-dependent miR-1 expression, leading to follistatin-mediated myocyte fusion.
A cation counterflux supports lysosomal acidification
Lysosomes lose cations to balance the influx of protons as the organelle acidifies.
