On the cover
Wilson et al. reveal that the endoplasmic reticulum protein Mia3 is required for the secretion of a variety of different collagen proteins. Chondrocytes from mice lacking Mia3 have a swollen ER, probably due to the abnormal retention of collagens. Image by Mei Sun, © 2011 Wilson et al.
See page 935.
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In This Issue
One collagen shipment, ready for delivery
An ER membrane protein helps load collagen into vesicles.
People & Ideas
Valerie Weaver: Overcoming cancer's stiff resistance
Weaver investigates the mechanical properties of tumors and how changes in the tumor microenvironment influence cancer cell behavior.
Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation
A combination of several rate-limiting steps allows for efficient control of alternative splicing.
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
WASH coats mature lysosomes and is required for exocytosis of indigestible material.
Caveolin-1–eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability
Caveolin-1–mediated inhibition of endothelial nitric oxide synthase signaling is essential for adherens junction integrity and endothelial permeability homeostasis.
RNA polymerase III drives alternative splicing of the potassium channel–interacting protein contributing to brain complexity and neurodegeneration
An RNA polymerase III–transcribed noncoding RNA promotes alternative splicing of KCNIP4, altering amyloid precursor protein processing and contributing to neurodegeneration.
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
Disturbed flow-mediated PKCζ–PIASy association is critical for p53 SUMOylation and induces p53 nuclear export and endothelial cell apoptosis.
Peroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1
De novo peroxisome formation in peroxisome-deficient yeast cells requires Rho1 and the Pex11 family protein Pex25.
SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain
The newly identified SYLF lipid-binding domain of SH3YL1 mediates phosphoinositide binding during dorsal membrane morphogenesis.
Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis
AKAP450 is a critical determinant of Golgi ribbon integrity, positioning, and function.
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
Mia3’s contribution to protein secretion is broader than previously realized—its absence impairs collagen deposition and normal development of cartilage and bone.