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Cover Image
Cover Image
On the cover
A mouse hippocampal neuron (red) shows numerous mushroom-shaped dendritic spines enriched in PSD-95 (green) along its dendrites. Lippi et al. reveal that the morphology of these structures is modulated by the expression of miRNAs that target the Arpc3 actin-nucleation factor. Image courtesy of Kenneth Young.
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In This Issue
In Focus
People & Ideas
Shinya Inoué: Lighting the way in microscopy
Inoué’s innovations in polarized light microscopy allowed the first documentation of the mitotic spindle in living cells.
Editorial
Review
Article
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis
Genome organizer Satb1 is regulated by p63 and contributes to epidermal morphogenesis by remodeling chromatin structure and gene expression at the epidermal differentiation complex locus.
MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
MCPH1, a protein linked to primary microcephaly, directly modulates condensin II to regulate chromosome condensation and shape.
CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly
CENP-C provides a link between existing CENP-A chromatin and the proteins required for new CENP-A nucleosome assembly.
Arf6 regulates AP-1B–dependent sorting in polarized epithelial cells
Activated Arf6 directs membrane recruitment of the clathrin adaptor AP-1B to maintain membrane polarization in epithelial cells.
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology
Regulation of Arpc3 by miRNA alters dendritic spine morphology.
GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis
GRK5 couples actin cytoskeleton dynamics to membrane remodeling during neuronal morphogenesis independent of its kinase activity.
S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development
S6 kinase localizes to the active zone in a Brp-dependent manner and collaborates with presynaptic PDK1 to modulate neuronal cell size, bouton size, active zone number, and neurotransmitter release.
