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Cover Image
Cover Image
On the cover
The distribution of different phosphoinositides in a multinuclear osteoclast is revealed by the localizations of GFP-AktPH (green) and RFP-PLCδ1PH (red). AktPH binds the phosphoinositides PtdIns(3,4)P2 and PtdIns (3,4,5)P3 , which are enriched in podosome-associated membrane protrusions that promote the fusion of osteoclast precursors.
Image courtesy of Tsukasa Oikawa.
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In This Issue
In Focus
miR-34s keep osteoblasts bone idle
An in vivo study reveals how an miRNA family inhibits osteoblast proliferation and differentiation.
People & Ideas
Fernando Camargo: No limits to learning about stem cells
Camargo studies the regulation of organ size and the biology of adult stem cells.
Review
Report
Fascin promotes filopodia formation independent of its role in actin bundling
Mutation of a critical residue of fascin eliminates the protein’s actin-bundling activity but maintains its positive role in filopodia formation
DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis
Reduced Drp1-mediated mitochondrial fission decreases cell cycle exit and prevents Notch-dependent follicle cell differentiation during oogenesis.
An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy
Simultaneous ion conductance and confocal microscopy in live cells reveal a new form of asymmetric clathrin-coated pit closure.
Article
miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2
miR-34b and -c inhibit osteoblast proliferation and differentiation by decreasing the levels of cell cycle proteins and of the nuclear matrix protein SATB2.
Stoichiometry for binding and transport by the twin arginine translocation system
Stoichiometry determined in this study suggests that the fully loaded and assembled Tat translocase is an ∼2.2-megadalton complex that can individually transport eight precursor proteins or cooperatively transport multimeric precursors.
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
Mitochondrial division serves as a quality control mechanism to suppress oxidative damage and thus promote neuronal survival.
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell–cell fusion
Tks5, a master regulator of invadopodia in cancer cells, is also crucial for osteoclast cell–cell fusion.
