On the cover
Neuroepithelial cells from mouse embryos lacking the intraflagellar transport complex A protein IFT144 have short, disorganized primary cilia and show decreased activation of the Sonic hedgehog signaling pathway.
Image courtesy of Karel Liem and Leslie Gunther-Cummins.
See page 789.
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In This Issue
Talin is cut out for intercellular adhesion
Study reveals that arginylation and proteolysis regulate this focal adhesion protein's function at cell–cell contacts.
People & Ideas
Alexey Khodjakov: Diving into the mitotic apparatus
Khodjakov uses cutting-edge microscopy to study how the mitotic spindle is organized.
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
Interaction of RGS proteins with orphan GPCRs promotes signaling compartmentalization and specificity.
2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen
In breast cancer cells, growth factor stimulation of membrane protrusion was a better predictor of 3D migration than 2D motility, cognate receptor expression, or receptor activation.
Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency
Nucleostemin is a novel cell reprogramming factor that promotes self-renewal and pluripotency through effects on gene expression and cell cycle progression.
Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
The P-site of the 60S ribosomal subunit signals to Tif6 via Elf1 during ribosomal maturation, suggesting a quasifunctional check of the integrity of the 60S subunit before the first round of translation.
Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase
The Hrd1 ubiquitin ligase plays a role in quality control of two substrates associated with the Sec61 translocon.
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation
Actomyosin dynamics and T cell receptor signaling are tightly coupled to ensure proper dynamics and function of signaling microclusters within the immunological synapse.
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
Mutations in mouse intraflagellar transport–A complex genes alter Sonic hedgehog signaling because of their effects on cilia structure and on trafficking of membrane proteins into cilia.
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior
FGFR1 cleavage by Granzyme B induces its nuclear translocation, in which it stimulates cell migration through effects on gene expression.
Arginylation-dependent regulation of a proteolytic product of talin is essential for cell–cell adhesion
A proteolytic fragment of talin is regulated by arginylation and promotes cadherin-dependent cell–cell adhesion.
Smooth muscle–endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation
Reelin signaling is activated by communication between the two cell types of the collecting lymphatic vessels and promotes smooth muscle cell recruitment, which is necessary for lymphatic vessel morphogenesis and function.