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In Focus

Phospholipid directs polarized growth by targeting actin-polymerizing formins to the cortex of plant cells.

People & Ideas

Vousden studies the activities and regulation of the tumor suppressor p53.



The mammalian meiosis-specific KASH protein KASH5 connects the telomere-associated SUN1 protein to the cytoplasmic force–generating mechanism involved in meiotic chromosome movement.

Repo-Man and Sds22 counteract Aurora B phosphorylation of Dsn1 and thus regulate the kinetochore–microtubule interface during anaphase.

ERK-mediated up-regulation of c-myc by K-Ras or B-Raf oncogenes disrupts the establishment of apical/basolateral polarity independently of its effect on proliferation.

Relatively stable microvillar components are linked in vivo by the scaffolding protein EBP50 in spite of its surprisingly high turnover rate.


The state of CENP-E–dependent BubR1 autophosphorylation in response to spindle microtubule capture regulates kinetochore function and accurate chromosome segregation.

Atg9-containing vesicles assemble to the preautophagosomal structure and eventually are incorporated into the autophagosomal outer membrane.

PI(3,5)P2 is directly linked to generation and remodeling of the cortical actin array by formin during polarized cell growth in plants.

Synaptic activity–dependent remodeling of the glutamate receptor scaffold complex generates a negative feedback loop that limits further NMDA receptor activation.

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