IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed, metabolic regulation is integrated into both the physiological and the pathogenic aspects of IL-17 responses. Thus, understanding the interplay between IL-17 and downstream metabolic processes could ultimately inform therapeutic opportunities for diseases involving IL-17, including some not traditionally linked to this cytokine pathway. Here, we discuss the emerging pathophysiological roles of IL-17 related to cellular and organismal metabolism, including metabolic regulation of IL-17 signal transduction.
The metabolism-modulating activity of IL-17 signaling in health and disease
Disclosures: The authors declare no competing interests exist.
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Rami Bechara, Mandy J. McGeachy, Sarah L. Gaffen; The metabolism-modulating activity of IL-17 signaling in health and disease. J Exp Med 3 May 2021; 218 (5): e20202191. doi: https://doi.org/10.1084/jem.20202191
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