The development of glomerulonephritis in NZB/W mice is closely related to the formation of antinuclear, particularly anti-DNA, antibodies. The developing inflammatory glomerular lesions are characterized by the deposition of γG- and ß1C-globulins plus DNA and possibly other nuclear antigens, presumably as complexes, in a granular to lumpy pattern along the capillary walls and in the mesangia. Elution studies revealed the γG-globulin in the glomeruli to be largely γG2A-type antibody to soluble nuclear antigens. Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis. Similarly, injections of soluble DNA into NZB/W mice with circulating anti-DNA antibodies but with as yet little nephritis causes rapid progression of nephritis.
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March 01 1968
PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE
P. H. Lambert,
P. H. Lambert
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
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Frank J. Dixon
Frank J. Dixon
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
P. H. Lambert
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Frank J. Dixon
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Received:
November 04 1967
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1968 by The Rockefeller University Press
1968
J Exp Med (1968) 127 (3): 507–522.
Article history
Received:
November 04 1967
Citation
P. H. Lambert, Frank J. Dixon; PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE . J Exp Med 1 March 1968; 127 (3): 507–522. doi: https://doi.org/10.1084/jem.127.3.507
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