Investigation into the antigenicity of streptococcal lipoproteinase has revealed the existence of multiple, immunologically distinct enzymes. Each lipoproteinase identified was found to be strain specific in that it was found only in strains of a particular T-agglutination pattern. In some T patterns, all streptococci of that T pattern which were examined shared a common lipoproteinase antigen. In other T patterns, strains which produced antigenically different lipoproteinases were identified. Evidence that the lipoproteinase antigen is distinct from other well-established cellular antigens of Group A streptococci has been presented. The production of this strain-specific enzyme by strains currently difficult to type by the standard M precipitin method may facilitate more precise identification of these strains and a better assessment of their role in the pathogenesis of Group A streptococcal infections and their sequelae.
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May 01 1968
THE SERUM OPACITY REACTION OF STREPTOCOCCUS PYOGENES : THE DEMONSTRATION OF MULTIPLE, STRAIN-SPECIFIC LIPOPROTEINASE ANTIGENS
Franklin H. Top, Jr.,
Franklin H. Top, Jr.
From the Departments of Pediatrics and Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
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Lewis W. Wannamaker
Lewis W. Wannamaker
From the Departments of Pediatrics and Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Search for other works by this author on:
Franklin H. Top, Jr.
From the Departments of Pediatrics and Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Lewis W. Wannamaker
From the Departments of Pediatrics and Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Received:
December 26 1967
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1968 by The Rockefeller University Press
1968
J Exp Med (1968) 127 (5): 1013–1034.
Article history
Received:
December 26 1967
Citation
Franklin H. Top, Lewis W. Wannamaker; THE SERUM OPACITY REACTION OF STREPTOCOCCUS PYOGENES : THE DEMONSTRATION OF MULTIPLE, STRAIN-SPECIFIC LIPOPROTEINASE ANTIGENS . J Exp Med 1 May 1968; 127 (5): 1013–1034. doi: https://doi.org/10.1084/jem.127.5.1013
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