These experiments have shown that salvarsan is a comparatively inactive drug when applied directly to nerve and muscle tissue of the frog. In perfusion experiments with alkaline solutions, no detrimental action whatever was to be seen either upon direct or indirect irritability. In bathing .experiments, in which the concentration of the salvarsan in the various solutions was surely much higher than that in which it reaches the peripheral tissues in the human subject through the circulation, the loss of irritability occurred only after a long period of exposure to the drug.
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Article| June 01 1911
A FEW OBSERVATIONS ON THE ACTION OF SALVARSAN UPON THE IRRITABILITY OF NERVE AND MUSCLE
Don R. Joseph
From the Department of Physiology and Pharmacology of the Rockefeller Institute for Medical Research, New York.
Received: April 15 1911
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1911, by The Rockefeller Institute for Medical Research New York
Don R. Joseph; A FEW OBSERVATIONS ON THE ACTION OF SALVARSAN UPON THE IRRITABILITY OF NERVE AND MUSCLE . J Exp Med 1 June 1911; 13 (6): 634–637. doi: https://doi.org/10.1084/jem.13.6.634
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