These experiments have shown that salvarsan is a comparatively inactive drug when applied directly to nerve and muscle tissue of the frog. In perfusion experiments with alkaline solutions, no detrimental action whatever was to be seen either upon direct or indirect irritability. In bathing .experiments, in which the concentration of the salvarsan in the various solutions was surely much higher than that in which it reaches the peripheral tissues in the human subject through the circulation, the loss of irritability occurred only after a long period of exposure to the drug.

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