Peritoneal exudate lymphocytes from guinea pigs immunized with horse radish peroxidase, dinitrophenyl guinea pig albumin, or ferritin in complete Freund's adjuvant have been shown to be significantly more reactive than other lymphocytes in two in vitro assays of cellular immune function: production of macrophage migration inhibitory factor and antigen-induced lymphocyte proliferation. The enhanced reactivity of peritoneal exudate lymphocytes cannot be accounted for by artifacts introduced by column purification or by the presence of nonlymphoid accessory cells. These observations suggest that the peritoneal exudate lymphocyte pool is a highly enriched source of cellular immune effector cells with specificity directed towards those antigenic determinants to which an animal has been recently exposed.
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November 01 1971
THE PERITONEAL EXUDATE LYMPHOCYTE : I. DIFFERENCES IN ANTIGEN RESPONSIVENESS BETWEEN PERITONEAL EXUDATE AND LYMPH NODE LYMPHOCYTES FROM IMMUNIZED GUINEA PIGS
David L. Rosenstreich,
David L. Rosenstreich
From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
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J. Thomas Blake,
J. Thomas Blake
From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
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Alan S. Rosenthal
Alan S. Rosenthal
From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
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David L. Rosenstreich
From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
J. Thomas Blake
From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
Alan S. Rosenthal
From the Laboratory of Clinical Investigation, National Institute of Allergy and, Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
Received:
June 23 1971
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 134 (5): 1170–1186.
Article history
Received:
June 23 1971
Citation
David L. Rosenstreich, J. Thomas Blake, Alan S. Rosenthal; THE PERITONEAL EXUDATE LYMPHOCYTE : I. DIFFERENCES IN ANTIGEN RESPONSIVENESS BETWEEN PERITONEAL EXUDATE AND LYMPH NODE LYMPHOCYTES FROM IMMUNIZED GUINEA PIGS . J Exp Med 1 November 1971; 134 (5): 1170–1186. doi: https://doi.org/10.1084/jem.134.5.1170
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