When thymus cells which are unresponsive to LPS are combined with numbers of peripheral lymphoid cells giving minimal responses to LPS, synergistic incorporation of [3H]thymidine occurs. Synergy requires that both components proliferate, but most of the augmented response is the result of peripheral cell proliferation. The thymus cell is a T cell of variable density, low in thy-1.2 antigen, not concanavalin A responsive, present in the major thymus subpopulation, and may be from lipopolysaccharide (LPS)-unresponsive strains. The peripheral cell is sensitive to anti-IgG or IgM plus complement (C'), resistant to anti-Thy-1.2 and C', exhibits adherence properties of B lymphocytes, and must be from LPS-responsive strains. Synergistic responses depend on critical thymus/peripheral cell ratios, inhibition occurring at high peripheral cell numbers. The data provide evidence that B-cell proliferative responses to LPS may be regulated by a subclass of thymus T cells.
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May 01 1977
Regulation of B-cell proliferative responses to lipopolysaccharide by a subclass of thymus T cells.
M A Norcross
R T Smith
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1977) 145 (5): 1299–1315.
Citation
M A Norcross, R T Smith; Regulation of B-cell proliferative responses to lipopolysaccharide by a subclass of thymus T cells.. J Exp Med 1 May 1977; 145 (5): 1299–1315. doi: https://doi.org/10.1084/jem.145.5.1299
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