Evidence is presented that T cells that produce lethal graft-vs.-host disease (GVHD) to minor histocompatibility antigens (minor HA) comprise discrete subgroups of H-2K- and H-2D-restricted T cells; double negative selection of T cells in irradiated H-2 recombinant mice was used to separate these two subgroups. No evidence could be found that I-restricted T cells contributed to GVHD, either as effector cells or helper cells. The (unprimed) precursor cells for GVHD expressed the Thy-1+, Lyt-1+/-2, Ia- phenotype. Studies in which H-2-semiallogeneic bone marrow chimeras were used as hosts for negative selection suggested that presentation of minor HA to T cells during the induction phase is controlled by marrow-derived cells; indirect evidence was obtained that these latter cells can "process" minor HA presented on H-2 different cells and thereby render the antigens immunogenic. Studies in which minor HA-different, H-2-compatible chimeras were re-irradiated and then injected with donor-vs.-host T cells suggested that the effector phase of lethal GVHD involves contact of antigen on non-marrow-derived cells.
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Article| March 01 1982
Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1982) 155 (3): 872–883.
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R Korngold, J Sprent; Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers.. J Exp Med 1 March 1982; 155 (3): 872–883. doi: https://doi.org/10.1084/jem.155.3.872
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