The IL-2R is composed of at least two subunits, the p55 (CD25/Tac) and p75 glycoproteins. The p75 IL-2R is expressed preferentially on resting human peripheral blood NK cells, but is not detected on substantial proportions of T and B lymphocytes, monocytes, or granulocytes. Anti-p75 IL-2R mAb substantially inhibits the early events associated with NK cell activation by IL-2, including inhibition of cytotoxic activity and induction of the CD69 early activation antigen. While anti-p55 IL-2R mAb alone failed to substantially inhibit the initial events of IL-2 stimulation, maximal inhibition of IL-2-induced cytotoxicity and proliferation was achieved by combining both anti-p55 IL-2R and anti-p75 IL-2R. Collectively, results from the present studies directly implicate the p75 IL-2R as the structure predominantly responsible for IL-2 activation of NK cells.
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July 01 1989
Activation of natural killer cells via the p75 interleukin 2 receptor.
J H Phillips,
J H Phillips
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
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T Takeshita,
T Takeshita
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
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K Sugamura,
K Sugamura
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
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L L Lanier
L L Lanier
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
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J H Phillips
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
T Takeshita
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
K Sugamura
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
L L Lanier
Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1989) 170 (1): 291–296.
Citation
J H Phillips, T Takeshita, K Sugamura, L L Lanier; Activation of natural killer cells via the p75 interleukin 2 receptor.. J Exp Med 1 July 1989; 170 (1): 291–296. doi: https://doi.org/10.1084/jem.170.1.291
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