It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.
Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.
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C P Larsen, P J Morris, J M Austyn; Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.. J Exp Med 1 January 1990; 171 (1): 307–314. doi: https://doi.org/10.1084/jem.171.1.307
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