The effects of allogeneic bone marrow transplantation (BMT) on non-insulin-dependent diabetes mellitus (NIDDM) were examined using KK-Ay mice. KK-Ay mice reconstituted with KK-Ay bone marrow cells showed glycosuria, hyperinsulinemia, and hyperlipidemia. However, KK-Ay mice (H-2b) that had been lethally irradiated (9.0 Gy) and then reconstituted with T cell-depleted bone marrow cells from normal BALB/c mice (H-2d) showed negative urine sugar with decreases in serum insulin and lipid levels 4 mo after BMT. Morphological recovery of islets and glomeruli was also noted after allogeneic BMT. These findings suggest that BMT can be used to treat not only a certain type of NIDDM but also its complications such as hyperlipidemia and diabetic nephropathy.
Skip Nav Destination
Article navigation
Article|
October 01 1992
Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice.
S Than,
S Than
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
H Ishida,
H Ishida
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
M Inaba,
M Inaba
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
Y Fukuba,
Y Fukuba
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
Y Seino,
Y Seino
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
M Adachi,
M Adachi
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
H Imura,
H Imura
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
S Ikehara
S Ikehara
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Search for other works by this author on:
S Than
First Department of Pathology, Kansai Medical University, Osaka, Japan.
H Ishida
First Department of Pathology, Kansai Medical University, Osaka, Japan.
M Inaba
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Y Fukuba
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Y Seino
First Department of Pathology, Kansai Medical University, Osaka, Japan.
M Adachi
First Department of Pathology, Kansai Medical University, Osaka, Japan.
H Imura
First Department of Pathology, Kansai Medical University, Osaka, Japan.
S Ikehara
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1992) 176 (4): 1233–1238.
Citation
S Than, H Ishida, M Inaba, Y Fukuba, Y Seino, M Adachi, H Imura, S Ikehara; Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice.. J Exp Med 1 October 1992; 176 (4): 1233–1238. doi: https://doi.org/10.1084/jem.176.4.1233
Download citation file:
Suggested Content
Email alerts
Advertisement