Lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 (LFA-1/ICAM-1)-and very late antigen 4/vascular cell adhesion molecule 1 (VLA-4/VCAM-1)-mediated adhesion of T lymphocytes to endothelial cells (EC) can be regulated by increased expression of ICAM-1 and VCAM-1 upon cytokine treatment of EC, or by activation of the integrin molecules LFA-1 and VLA-4 on T cells. Here, we provide evidence that preferential usage of LFA-1 over VLA-4 is yet another mechanism to control T cell adhesion. We observed that binding of activated T lymphocytes, as opposed to resting T cells, to EC is essentially mediated through LFA-1 and not through VLA-4. VLA-4-mediated adhesion of T cells to EC is only found when LFA-1 is not expressed or not functional, as observed for several T cell leukemia cell lines. These results suggest that LFA-1-mediated adhesion dominates and may downregulate VLA-4-mediated adhesion through an unidentified mechanism.
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January 01 1993
Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium.
Y van Kooyk,
Y van Kooyk
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
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E van de Wiel-van Kemenade,
E van de Wiel-van Kemenade
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
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P Weder,
P Weder
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
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R J Huijbens,
R J Huijbens
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
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C G Figdor
C G Figdor
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
Search for other works by this author on:
Y van Kooyk
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
E van de Wiel-van Kemenade
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
P Weder
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
R J Huijbens
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
C G Figdor
Division of Immunology, Netherlands Cancer Institute, Amsterdam.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1993) 177 (1): 185–190.
Citation
Y van Kooyk, E van de Wiel-van Kemenade, P Weder, R J Huijbens, C G Figdor; Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium.. J Exp Med 1 January 1993; 177 (1): 185–190. doi: https://doi.org/10.1084/jem.177.1.185
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