Human class I major histocompatibility complex allele HLA-B27 is associated with a group of human diseases called "spondyloarthropathies." Studies on transgenic rats expressing HLA-B27 and human beta 2-microglobulin have confirmed the role of HLA-B27 in disease pathogenesis. Here we report spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin (B27+ beta 2m-/-). In the absence of beta 2-microglobulin, B27+ beta 2m-/- animals do not express the HLA-B27 transgene on the cell surface and have a very low level of CD8+ T cells. Most of the B27+ beta 2m-/- male mice showed nail changes, hair loss, and swelling in paws, which leads to ankylosis. The symptoms occur only after the B27+ beta 2m-/- mice are transferred from the specific pathogen-free mouse colony. These results suggest that aberrant assembly, transport, and expression of the HLA-B27 molecule may predispose an individual for development of the disease when exposed to an appropriate environmental trigger.
Skip Nav Destination
Article navigation
Article|
October 01 1995
Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies.
S D Khare,
S D Khare
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55902, USA.
Search for other works by this author on:
H S Luthra,
H S Luthra
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55902, USA.
Search for other works by this author on:
C S David
C S David
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55902, USA.
Search for other works by this author on:
S D Khare
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55902, USA.
H S Luthra
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55902, USA.
C S David
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55902, USA.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1995) 182 (4): 1153–1158.
Citation
S D Khare, H S Luthra, C S David; Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies.. J Exp Med 1 October 1995; 182 (4): 1153–1158. doi: https://doi.org/10.1084/jem.182.4.1153
Download citation file:
Suggested Content
Email alerts
Advertisement