We are starting the New Year with an updated look and new content. The JEM has never been fashion conscious, and its distinctive format has changed very little over 109 years. It is an advantage to be instantly recognizable amidst the sea of PDF printouts found on most scientists' desks, so we have preserved the essential look of the Articles and Brief Definitive Reports. The new design is, however, tidier and thus easier to read.

More important than the change in style and the splash of color on the contents pages is the new content we are adding. “In This Issue” stories will highlight papers of special interest, explaining why we are excited about the advance. We hope that these short, accessible stories will attract you to read interesting papers outside of your immediate areas of expertise. Commentaries, which have an updated, more colorful look, will continue to give a more personal perspective on recent advances published in the JEM and elsewhere, providing the nonspecialist reader with insight into rapidly developing fields.

We are also initiating a new series of articles highlighting the many landmark papers that have been published in the pages of the JEM over the years. JEM Editors and Advisory Editors, past and present, have been helping us to identify groundbreaking papers that have shaped current biomedical research. If there is a particular JEM paper that you are still regularly citing more than a decade later, or if you uncover a gem in the archive, we'd be delighted to hear from you. Our News Editor Heather Van Epps kicks off this greatest hits series by discussing the papers that triggered immunologists' fascination with lymphocyte subsets.

These stories will provide another excuse to delve into the online archive—an extraordinary collection of 109 years of science at its best. The complete collection of JEM papers, starting from the 1896 publication of Volume 1, Issue 1, is available free online in PDF format. You can browse issue by issue or search the full text. Given the JEM's long and illustrious history, we don't expect to run out of papers to write about any time soon.