1. A vaccine prepared from partially defatted bovine tubercle bacilli influenced favorably the survival time after inoculation with living virulent bovine tubercle bacilli.

2. Accompanying this increased resistance was a sustained lymphocytosis in the vaccinated animals.

3. The vaccine induced a transitory anemia and leucopenia.

4. A similar preparation of partially defatted human tubercle bacilli possessed the power to sensitize guinea pigs to tuberculo-protein.

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