The intravenous injection of Shiga toxin into dogs causes a rise in hemoglobin, red blood cell count, hematocrit reading, and specific gravity of the whole blood. There is thus a decrease in circulating blood volume. The specific gravity of the blood plasma does not change. These findings indicate that the toxin of B. shigae produces a shock-like circulatory state. As a result there occurs a compensatory vasoconstriction in the duodenum of the dog and in the cecum of the rabbit. It has been shown that the toxin of B. shigae has no direct effect upon the intestinal mucosa when brought into contact therewith, but that its absorption through the mucosa leads to the appearance of a lesion in the duodenum of the dog. Therefore we interpret the pathological alterations in the intestinal tract, following the injection of Shiga toxin, as the anatornic end result of a pronounced and prolonged homeostatic vasoconstriction.
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September 01 1942
STUDIES IN THE PATHOGENESIS OF EXPERIMENTAL DYSENTERY INTOXICATION
Abraham Penner,
Abraham Penner
From the Laboratories of The Mount Sinai Hospital, New York
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Alice Ida Bernheim
Alice Ida Bernheim
From the Laboratories of The Mount Sinai Hospital, New York
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Abraham Penner
From the Laboratories of The Mount Sinai Hospital, New York
Alice Ida Bernheim
From the Laboratories of The Mount Sinai Hospital, New York
Received:
March 10 1942
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1942, by The Rockefeller Institute for Medical Research New York
1942
J Exp Med (1942) 76 (3): 271–282.
Article history
Received:
March 10 1942
Citation
Abraham Penner, Alice Ida Bernheim; STUDIES IN THE PATHOGENESIS OF EXPERIMENTAL DYSENTERY INTOXICATION . J Exp Med 1 September 1942; 76 (3): 271–282. doi: https://doi.org/10.1084/jem.76.3.271
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