Mucormycosis was produced in rabbits with sustained, severe leukopenia and granulocytopenia induced by repeated injections of nitrogen mustard. Initially, these animals developed extensive fungus lesions at the site of inoculation which later became granulomatous and tended to heal. Only the early phases of host resistance appeared impaired by the virtual elimination of the polymorphonuclear leukocyte as a factor in the host response. Despite the persistent leukopenia and granulocytopenia, the later phases of host resistance resembled those of the normal animal. Thus, the behavior of the infection in this experiment differs greatly from the unchecked progression of mucormycosis in the metabolically abnormal animal with acute alloxan diabetes. The differences in the course of the disease and in the morphologic appearance of the lesions indicate that metabolic alterations in the host affect all phases of host resistance and not only the polymorphonuclear leukocytic response.
Article|
October 01 1957
LEUKOPENIA WITH GRANULOCYTOPENIA IN EXPERIMENTAL MUCORMYCOSIS (RHIZOPUS ORYZAE INFECTION
Heinz Bauer,
Heinz Bauer
From The Department of Pathology, Emory University School of Medicine, Emory University
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Walter H. Sheldon
Walter H. Sheldon
From The Department of Pathology, Emory University School of Medicine, Emory University
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Heinz Bauer
From The Department of Pathology, Emory University School of Medicine, Emory University
Walter H. Sheldon
From The Department of Pathology, Emory University School of Medicine, Emory University
Received:
May 27 1957
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1957, by The Rockefeller Institute for Medical Research New York
1957
J Exp Med (1957) 106 (4): 501–508.
Article history
Received:
May 27 1957
Citation
Heinz Bauer, Walter H. Sheldon; LEUKOPENIA WITH GRANULOCYTOPENIA IN EXPERIMENTAL MUCORMYCOSIS (RHIZOPUS ORYZAE INFECTION . J Exp Med 1 October 1957; 106 (4): 501–508. doi: https://doi.org/10.1084/jem.106.4.501
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