The renal lesions of serum sickness were studied with the electron microscope. The most prominent change was a marked swelling and proliferation of glomernlar endothelial cells causing obliteration of the capillary lumen. The basement membrane also showed focal thickenings and excrescences. Deposits of electron-dense material blended into the basement membrane. On the extracapillary side epithelial foot processes were reduced in number and replaced by broad sheets of cytoplasm which were closely applied to the basement membrane. From a comparison of electron and fluorescent microscopic studies of the glomerulus in serum sickness, it would seem that antigen-antibody complexes initiated injury in endothelial cells, although the possibility of the primary reaction occurring on basement membrane cannot be excluded.
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December 01 1958
ELECTRON MICROSCOPY OF SERUM SICKNESS NEPHRITIS
Joseph D. Feldman
Joseph D. Feldman
From the Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh
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Joseph D. Feldman
From the Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh
Received:
June 30 1958
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1958, by The Rockefeller Institute
1958
J Exp Med (1958) 108 (6): 957–962.
Article history
Received:
June 30 1958
Citation
Joseph D. Feldman; ELECTRON MICROSCOPY OF SERUM SICKNESS NEPHRITIS . J Exp Med 1 December 1958; 108 (6): 957–962. doi: https://doi.org/10.1084/jem.108.6.957
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