The fate of injected S35-labeled sulfanilic acid-azoalbumin in the serum, various organs, and liver fractions was compared in the newborn and adult rabbit and in specifically unresponsive and normal adult rabbits. Exponential decay of the injected antigen without the usual immune phase of elimination was observed in newborn and unresponsive adult animals. Comparison of organ distribution of radioactivity in adults and animals injected at birth and 21 days of age showed persistence in the liver at least as long as 3 weeks in all groups (which was the time chosen for observation). The slight differences in spleen and thymus concentrations with age are of undetermined significance. Comparison of the organ distribution of antigen in unresponsive adult rabbits and in normal ones showed slight differences which were similar to those predicted from previous immunization of adults which gave low grade antibody response. There was a slight selective accumulation of antigen in the nuclear fraction of liver homogenates of unresponsive animals, but no other differences were observed.
Article|
September 01 1960
THE DISTRIBUTION OF S35-LABELED BOVINE SERUM ALBUMIN IN NEWBORN AND IMMUNOLOGICALLY TOLERANT ADULT RABBITS
Justine S. Garvey,
Justine S. Garvey
From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, and the Department of Pediatrics, University of Florida College of Medicine, Gainesville
Search for other works by this author on:
Donald V. Eitzman,
Donald V. Eitzman
From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, and the Department of Pediatrics, University of Florida College of Medicine, Gainesville
Search for other works by this author on:
Richard T. Smith
Richard T. Smith
From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, and the Department of Pediatrics, University of Florida College of Medicine, Gainesville
Search for other works by this author on:
Justine S. Garvey
From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, and the Department of Pediatrics, University of Florida College of Medicine, Gainesville
Donald V. Eitzman
From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, and the Department of Pediatrics, University of Florida College of Medicine, Gainesville
Richard T. Smith
From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena, and the Department of Pediatrics, University of Florida College of Medicine, Gainesville
Received:
May 09 1960
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1960, by The Rockefeller Institute
1960
J Exp Med (1960) 112 (3): 533–550.
Article history
Received:
May 09 1960
Citation
Justine S. Garvey, Donald V. Eitzman, Richard T. Smith; THE DISTRIBUTION OF S35-LABELED BOVINE SERUM ALBUMIN IN NEWBORN AND IMMUNOLOGICALLY TOLERANT ADULT RABBITS . J Exp Med 1 September 1960; 112 (3): 533–550. doi: https://doi.org/10.1084/jem.112.3.533
Download citation file: