Seven strains of influenza A2 virus were serially passed in the chick embryo, and morphological characteristics of the passages were examined in the electron microscope. With serial passage there was a change from a prominently filamentous appearance in early passages to an almost entirely spherical appearance in later passages. The number of passages required for the conversion to spherical morphology varied with different strains. The filament-sphere variation was found to be independent of the properties which differentiate "+" and "-" influenza A2 virus particles, and both highly filamentous and spherical populations of "+" and of "-" virus particles were obtained. The usefulness of these pairs of independent markers for genetic studies is discussed.
Article|
November 01 1960
STUDIES OF TWO KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA A2 VIRUS STRAINS : III. MORPHOLOGICAL CHARACTERISTICS: INDEPENDENCE OF MORPHOLOGICAL AND FUNCTIONAL TRAITS
Purnell W. Choppin,
Purnell W. Choppin
From The Rockefeller Institute
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James S. Murphy,
James S. Murphy
From The Rockefeller Institute
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Igor Tamm
Igor Tamm
From The Rockefeller Institute
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Purnell W. Choppin
From The Rockefeller Institute
James S. Murphy
From The Rockefeller Institute
Igor Tamm
From The Rockefeller Institute
Received:
July 01 1960
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1960, by The Rockefeller Institute
1960
J Exp Med (1960) 112 (5): 945–952.
Article history
Received:
July 01 1960
Citation
Purnell W. Choppin, James S. Murphy, Igor Tamm; STUDIES OF TWO KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA A2 VIRUS STRAINS : III. MORPHOLOGICAL CHARACTERISTICS: INDEPENDENCE OF MORPHOLOGICAL AND FUNCTIONAL TRAITS . J Exp Med 1 November 1960; 112 (5): 945–952. doi: https://doi.org/10.1084/jem.112.5.945
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