Gross and microscopic observations of skin homograft rejection carried out in cortisone-conditioned and non-conditioned rabbits seem to indicate that humoral antibodies play an important role in the phenomenon. Thus, local administration of isoimmune serum to animals bearing skin homografts resulted in a significantly earlier rejection of that particular test graft without modifying the course of a neighboring control-skin graft. This result appears to support the idea that homograft rejection is not only due to cellular antibodies but to a combination of both humoral and cellular immune responses, which should not be regarded as completely unrelated.
THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS
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Roberto R. Kretschmer, Ruy Peréz-Tamayo; THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS . J Exp Med 1 October 1961; 114 (4): 509–520. doi: https://doi.org/10.1084/jem.114.4.509
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