Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37°C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.
EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO
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Roger M. Des Prez, Herbert I. Horowitz, Edward W. Hook; EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO . J Exp Med 1 December 1961; 114 (6): 857–874. doi: https://doi.org/10.1084/jem.114.6.857
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