Guinea pig 7Sγ1 antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ2 antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ2 antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.
PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
Zoltan Ovary, Baruj Benacerraf, Kurt J. Bloch; PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS . J Exp Med 1 June 1963; 117 (6): 951–964. doi: https://doi.org/10.1084/jem.117.6.951
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