Passive transfer of homograft immunity was successfully achieved by injection of the supernatant obtained from tissue-sensitized lymphoid cells disrupted by sonic vibration. The effective substance destroyed specific skin homografts within 6 days but did not reject non-specific skin grafts in this time. No evidence of transferred antigen or of transfer factor was found when the effective material was passed to irradiated recipients carrying test grafts. By a variety of physiochemical procedures the "soluble substance" behaved like a gamma globulin and was considered to be a transplantation antibody.
PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY : IV. TRANSPLANTATION ANTIBODY FROM EXTRACTS OF SENSITIZED LYMPHOID CELLS
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J. S. Najarian, J. D. Feldman; PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY : IV. TRANSPLANTATION ANTIBODY FROM EXTRACTS OF SENSITIZED LYMPHOID CELLS . J Exp Med 1 November 1963; 118 (5): 759–766. doi: https://doi.org/10.1084/jem.118.5.759
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