Serum transferrins have been examined in 392 samples from full-term infants and from premature infants at various stages of growth. The characteristic transferrin pattern of the infants by starch gel electrophoresis contained a single prominent iron-binding component accompanied by 4 faint, slower migrating components. An additional faint component was present in the sera of infants heterozygous for a transferrin variant. The faint components migrated slightly more rapidly than the corresponding components in the stepwise pattern produced by the action of neuraminidase in removing sialic acid from transferrin. The interpretation is presented that the faint components may represent the absence of multi-unit carbohydrate prosthetic groups on the transferrin molecule in the infant. A similar interpretation is possible for the slow migrating transferrins of cerebrospinal fluid.
Article|
December 01 1963
ADDITIONAL STUDIES ON THE TRANSFERRINS OF CORD SERUM AND CEREBROSPINAL FLUID : VARIATION IN CARBOHYDRATE PROSTHETIC GROUPS
W. Carey Parker,
W. Carey Parker
From The Rockefeller Institute and The New York Hospital-Cornell Medical Center, New York
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Jack W. C. Hagstrom,
Jack W. C. Hagstrom
From The Rockefeller Institute and The New York Hospital-Cornell Medical Center, New York
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Alexander G. Bearn
Alexander G. Bearn
From The Rockefeller Institute and The New York Hospital-Cornell Medical Center, New York
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W. Carey Parker
From The Rockefeller Institute and The New York Hospital-Cornell Medical Center, New York
Jack W. C. Hagstrom
From The Rockefeller Institute and The New York Hospital-Cornell Medical Center, New York
Alexander G. Bearn
From The Rockefeller Institute and The New York Hospital-Cornell Medical Center, New York
Received:
August 15 1963
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1963, by The Rockefeller Institute
1963
J Exp Med (1963) 118 (6): 975–989.
Article history
Received:
August 15 1963
Citation
W. Carey Parker, Jack W. C. Hagstrom, Alexander G. Bearn; ADDITIONAL STUDIES ON THE TRANSFERRINS OF CORD SERUM AND CEREBROSPINAL FLUID : VARIATION IN CARBOHYDRATE PROSTHETIC GROUPS . J Exp Med 1 December 1963; 118 (6): 975–989. doi: https://doi.org/10.1084/jem.118.6.975
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