It has been demonstrated that polymers consisting solely of D-α-amino acids are not immunogenic in rabbits, guinea pigs, man, and mouse, whereas the same polymers of L-α-amino acids are very effective antigens. This has been attributed to the importance of metabolizability of a polymer in contributing to its immunogenicity. In the glu-lys-ala series of polymers, the immunogenicity of a polymer of 2 L-amino acids and a D-amino acid appears to be governed by the immunogenicity of the 2 L-amino acids. However, some of the specificity may be directed towards configurations containing the D-amino acid. It has been noted that injections of rabbits with polymers of D-amino acids has resulted in a reduced response against the isomeric L polymer.
ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XIII. IMMUNOLOGICAL STUDIES WITH SYNTHETIC POLYMERS CONTAINING ONLY D- OR D- AND L-α-AMINO ACIDS
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Paul H. Maurer; ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XIII. IMMUNOLOGICAL STUDIES WITH SYNTHETIC POLYMERS CONTAINING ONLY D- OR D- AND L-α-AMINO ACIDS . J Exp Med 1 March 1965; 121 (3): 339–349. doi: https://doi.org/10.1084/jem.121.3.339
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