The mouse isoantigens determined at the major histocompatibility locus known as H-2 have been found to be closely associated with the cellular surface membranes, with the membranes of the endoplasmic reticulum, and probably with those of the lysosomes as well. Mitochondrial membranes, on the other hand, show little or no H-2 antigen activity. Membrane material prepared from certain tissues, including brain and muscle, have no detectable H-2 antigenic activity. Evidence is presented which indicates that all of the H-2 antigens of the genome are expressed as a unit, supporting the hypothesis that the complex H-2 genetic locus consists of a single cistron. It is postulated that these histocompatibility antigens form some structural or functional unit in the membranes of cells.
Article|
April 01 1965
THE EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS ON CELLULAR AND SUBCELLULAR MEMBRANES
Ronald Herberman,
Ronald Herberman
From the Department of Pathology, New York University College of Medicine, New York
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Chandler A. Stetson, Jr.
Chandler A. Stetson, Jr.
From the Department of Pathology, New York University College of Medicine, New York
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Ronald Herberman
From the Department of Pathology, New York University College of Medicine, New York
Chandler A. Stetson, Jr.
From the Department of Pathology, New York University College of Medicine, New York
Received:
November 29 1964
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1965 by The Rockefeller Institute
1965
J Exp Med (1965) 121 (4): 533–549.
Article history
Received:
November 29 1964
Citation
Ronald Herberman, Chandler A. Stetson; THE EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS ON CELLULAR AND SUBCELLULAR MEMBRANES . J Exp Med 1 April 1965; 121 (4): 533–549. doi: https://doi.org/10.1084/jem.121.4.533
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