Heat-killed Group A hemolytic streptococci can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. The gross and histologic appearance of these grafts is identical with that observed in similar reactions obtained in guinea pigs sensitized with homologous tissues. The ability of Group A hemolytic streptococci to induce homograft sensitivity in the guinea pig is a property shared by Types 4, 5, 6, 11, 12, 14, and 49 of Group A streptococci.
Article|
October 01 1965
THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI
Randolph M. Chase, Jr.,
Randolph M. Chase, Jr.
From the Departments of Medicine and Surgery, and Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, and The Rockefeller University
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Felix T. Rapaport
Felix T. Rapaport
From the Departments of Medicine and Surgery, and Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, and The Rockefeller University
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Randolph M. Chase, Jr.
From the Departments of Medicine and Surgery, and Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, and The Rockefeller University
Felix T. Rapaport
From the Departments of Medicine and Surgery, and Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, and The Rockefeller University
Received:
May 17 1965
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1965 by The Rockefeller University Press
1965
J Exp Med (1965) 122 (4): 721–732.
Article history
Received:
May 17 1965
Citation
Randolph M. Chase, Felix T. Rapaport; THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : I. EFFECTS OF SENSITIZATION WITH GROUP A STREPTOCOCCI . J Exp Med 1 October 1965; 122 (4): 721–732. doi: https://doi.org/10.1084/jem.122.4.721
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