The incubation of mycoplasmas with human peripheral blood buffy coats resulted in the uptake of these microorganisms by more than 50% of the mononuclear cells. Mycoplasmas adhered to the plasma membranes of all leukocytes, most of which developed long cytoplasmic processes not seen in the controls. In human and rat thoracic duct lymph, about 6% of the cells ingested the microorganisms. T2 phage and thorotrast were taken up by a similar percentage of lymphocytes. On morphological grounds, the cells which were able to take up PPLO's or particles could not be distinguished from the cells which were incapable of this function. Following phagocytosis, neither the cell nor the microorganism showed any morphological alterations over a 3 hr period of observation. The demonstration that a small percentage of "lymphocytes" are able to phagocytose may have pathological and immunological implications.
Article|
September 01 1966
THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : II. MONOCYTES AND LYMPHOCYTES
Dorothea Zucker-Franklin,
Dorothea Zucker-Franklin
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York
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Morton Davidson,
Morton Davidson
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York
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Lewis Thomas
Lewis Thomas
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York
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Dorothea Zucker-Franklin
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York
Morton Davidson
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York
Lewis Thomas
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York
Received:
March 16 1966
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1966 by The Rockefeller University Press
1966
J Exp Med (1966) 124 (3): 533–542.
Article history
Received:
March 16 1966
Citation
Dorothea Zucker-Franklin, Morton Davidson, Lewis Thomas; THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : II. MONOCYTES AND LYMPHOCYTES . J Exp Med 1 September 1966; 124 (3): 533–542. doi: https://doi.org/10.1084/jem.124.3.533
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