Rabbits immunized to different heterologous renal antigens developed antibodies some of which are fixed to their own glomeruli (autoantibodies). These autoantibodies, reacting with the host's kidneys, were directed to those antigenic determinants which were present in identical or cross-reactive form in both the immunizing antigen and the kidneys of the host. Glomerulonephritis developed in some of the rabbits immunized to heterologous mammalian kidneys, but in none of those immunized to nonmammalian kidneys. The development of glomerulonephritis in the immunized rabbits appears to depend upon two factors: (a) the amount of autoantikidney antibody made to the common renal antigens; and (b) the quantity of the common antigens available in the host's kidneys. An amount of common antigen sufficient to fix a nephritogenic amount of antibody is essential for the development of disease.
Article|
January 01 1967
EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS
Emil R. Unanue,
Emil R. Unanue
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California
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Frank J. Dixon
Frank J. Dixon
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California
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Emil R. Unanue
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California
Frank J. Dixon
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California
Received:
August 26 1966
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1967 by The Rockefeller University Press
1967
J Exp Med (1967) 125 (1): 149–162.
Article history
Received:
August 26 1966
Citation
Emil R. Unanue, Frank J. Dixon; EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS . J Exp Med 1 January 1967; 125 (1): 149–162. doi: https://doi.org/10.1084/jem.125.1.149
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