Sheep antisera specific for the three major immunoglobulin groups of the rabbit, i.e. IgG (γ-chain), IgA (α-chain), and IgM (µ-chain), are each able to induce blast transformation of the peripheral lymphocytes of the rabbit when added to in vitro cultures. The per cent of lymphocytes transformed with each antiserum indicate that one-fourth of the peripheral lymphocytes carry or have the capacity to synthesize molecules of all three of the major immunoglobulin groups, and that the remaining three-fourths carry or have the capacity to synthesize only two (IgG and IgM). The data do not permit direct conclusions concerning the ability of a single cell to produce molecules belonging to more than one immunoglobulin group at the same time, or the ability of a given cell to make a transition from the synthesis of molecules of one immunoglobulin group to those of another group.
Article|
March 01 1967
STUDIES ON RABBIT LYMPHOCYTES IN VITRO : VI. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGA AND IGM
Stewart Sell
Stewart Sell
From the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
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Stewart Sell
From the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Received:
October 30 1966
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1967 by The Rockefeller University Press
1967
J Exp Med (1967) 125 (3): 393–400.
Article history
Received:
October 30 1966
Citation
Stewart Sell; STUDIES ON RABBIT LYMPHOCYTES IN VITRO : VI. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGA AND IGM . J Exp Med 1 March 1967; 125 (3): 393–400. doi: https://doi.org/10.1084/jem.125.3.393
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