Sulfinpyrazone and phenylbutazone block the aggregating action of collagen, antigen-antibody complexes, and gamma globulin-coated surfaces on blood platelets. These drugs do not block the action of ADP or thrombin. Inhibition of surface-induced aggregation appears to be the result of a decreased response of the platelets to surface stimuli, giving rise to diminished release of platelet constituents, such as ADP and serotonin. The intravenous infusion of these drugs produced results similar to those found in the in vitro experiments. Administration of phenylbutazone in doses sufficient to produce marked suppression of the platelet-collagen reaction impaired hemostatic plug formation at the ends of transected mesenteric vessels in rabbits. Since platelet function is considered a factor influencing platelet survival, the effect of phenylbutazone on platelet survival was examined. It was found that phenylbutazone prolonged platelet survival to more than twice the normal time and reduced platelet turnover by nearly 50%. These studies show that drugs which suppress platelet response to surface stimuli alter platelet function in vivo.
Article|
July 01 1967
ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDS
M. A. Packham,
M. A. Packham
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
Search for other works by this author on:
E. S. Warrior,
E. S. Warrior
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
Search for other works by this author on:
M. F. Glynn,
M. F. Glynn
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
Search for other works by this author on:
A. S. Senyi,
A. S. Senyi
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
Search for other works by this author on:
J. F. Mustard
J. F. Mustard
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
Search for other works by this author on:
M. A. Packham
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
E. S. Warrior
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
M. F. Glynn
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
A. S. Senyi
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
J. F. Mustard
From the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, and the Blood and Vascular Disease Research Unit, Departments of Pathology and Medicine, University of Toronto, Toronto, Ontario
Received:
February 06 1967
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1967 by The Rockefeller University Press
1967
J Exp Med (1967) 126 (1): 171–188.
Article history
Received:
February 06 1967
Citation
M. A. Packham, E. S. Warrior, M. F. Glynn, A. S. Senyi, J. F. Mustard; ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDS . J Exp Med 1 July 1967; 126 (1): 171–188. doi: https://doi.org/10.1084/jem.126.1.171
Download citation file: