Cytogenetic studies on 64 rat leukemias induced with 7,8,12- and 6,8,12-trimethylbenz(a)anthracene were performed. Highly distinctive changes were found repeatedly in one special pair of chromosomes. 10 leukemias (15.6%) showed the presence of stemline(s) with trisomy of the largest telocentric chromosome (C-1 trisomy). Another chromosome abnormality, elongation of one of the pairs of the same chromosome (long C-1), was found in 5 leukemias (7.8%) as the predominant stemline and in 7 other cases as a small cell population. This chromosome abnormality, despite slight differences in their elongation rate, was defined as a new specific chromosome abnormality. Other chromosome abnormalities not related with C-1 chromosome were found in 8 cases (12.5%). The remaining 41 leukemias (64.1%) had the predominant stemline with normal karyotype. From this study it appears that three structurally different hydrocarbon carcinogens, 7,12-dimethylbenz(a)anthracene and 7,8,12- and 6,8,12-trimethylbenz(a)anthracene act on blood-forming cells by a common specific mechanism.
Article|
February 01 1970
CYTOGENETIC STUDIES OF LEUKEMIA INDUCED BY 6,8,12- AND 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
Taketoshi Sugiyama,
Taketoshi Sugiyama
From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637
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Filomena P. Brillantes
Filomena P. Brillantes
From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637
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Taketoshi Sugiyama
From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637
Filomena P. Brillantes
From the Ben May Laboratory for Cancer Research, The University of Chicago, Chicago, Illinois 60637
Received:
September 12 1969
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1970 by The Rockefeller University Press
1970
J Exp Med (1970) 131 (2): 331–341.
Article history
Received:
September 12 1969
Citation
Taketoshi Sugiyama, Filomena P. Brillantes; CYTOGENETIC STUDIES OF LEUKEMIA INDUCED BY 6,8,12- AND 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE . J Exp Med 1 February 1970; 131 (2): 331–341. doi: https://doi.org/10.1084/jem.131.2.331
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