A partially purified blood group-like substance obtained from milk showed I activity with 2 of 21 anti-I sera. With these antisera, certain human ovarian cyst substances considered to be precursors of the A, B, H, Lea, and Leb substances also showed I activity comparable to the milk material. Strong I activity could be produced by one-stage periodate oxidation and Smith degradation of human ovarian cyst A and B substances, or of hog mucin A + H substance, or by mild acid hydrolysis of human saliva or ovarian cyst blood group B substance. The two sera indicate that I specificity appears at intermediate stages in the biosynthesis of the A, B, H, Lea, and Lea substances. Anti-I sera differ strikingly in their specificities, indicating substantial heterogeneity of the I determinants.
Article|
January 01 1971
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LEa, AND LEb BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
Ten Feizi,
Ten Feizi
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
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Elvin A. Kabat,
Elvin A. Kabat
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
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Giuseppe Vicari,
Giuseppe Vicari
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
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Byron Anderson,
Byron Anderson
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
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W. Laurence Marsh
W. Laurence Marsh
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
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Ten Feizi
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
Elvin A. Kabat
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
Giuseppe Vicari
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
Byron Anderson
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
W. Laurence Marsh
From the Departments of Microbiology, Neurology, and Human Genetics and Development, Columbia University, New York 10032, The Neurological Institute, Presbyterian Hospital, New York 10032, The Rockefeller University, New York 10021, and the New York Blood Center, New York 10021
Received:
August 11 1970
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 133 (1): 39–52.
Article history
Received:
August 11 1970
Citation
Ten Feizi, Elvin A. Kabat, Giuseppe Vicari, Byron Anderson, W. Laurence Marsh; IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LEa, AND LEb BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES . J Exp Med 1 January 1971; 133 (1): 39–52. doi: https://doi.org/10.1084/jem.133.1.39
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