Peritoneal exudates from rats which have survived an infection with L. monocytogenes can protect cyclophosphamide-treated recipients against a Listeria challenge. They are more effective in this respect than cells obtained from the spleen or thoracic duct lymph. Since exudate cells from normal rats and inocula prepared from the resident peritoneal cell populations of infected donors are unable to inhibit the challenge infection, the protective cells must belong to a class of lymphocytes that emerges from the blood in response to inflammation. It is significant therefore that thoracic duct lymphocytes formed during an acute Listeria infection can move into exudates induced by a variety of inflammatory stimuli. The affinity of newly formed lymphocytes for inflamed tissue points to a mechanism whereby the host marshalls its cellular defenses at sites of bacterial invasion. The tendency of short-lived lymphocytes to leave inflamed vessels might also explain their short-circulating life-span.
Article|
February 01 1971
THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES
F. T. Koster,
F. T. Koster
From the Trudeau Institute, Saranac Lake, New York 12983
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D. D. McGregor,
D. D. McGregor
From the Trudeau Institute, Saranac Lake, New York 12983
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G. B. Mackaness
G. B. Mackaness
From the Trudeau Institute, Saranac Lake, New York 12983
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F. T. Koster
From the Trudeau Institute, Saranac Lake, New York 12983
D. D. McGregor
From the Trudeau Institute, Saranac Lake, New York 12983
G. B. Mackaness
From the Trudeau Institute, Saranac Lake, New York 12983
Received:
September 23 1970
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 133 (2): 400–409.
Article history
Received:
September 23 1970
Citation
F. T. Koster, D. D. McGregor, G. B. Mackaness; THE MEDIATOR OF CELLULAR IMMUNITY : II. MIGRATION OF IMMUNOLOGICALLY COMMITTED LYMPHOCYTES INTO INFLAMMATORY EXUDATES . J Exp Med 1 February 1971; 133 (2): 400–409. doi: https://doi.org/10.1084/jem.133.2.400
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