A survey of a large number of human sera with the heavy chain genetic markers of the γ-globulin system has revealed an unusual gene complex which is inherited as a unit through two different families. The gene complex involves two pairs of γG1 genetic markers which ordinarily behave as homoalleles, Gmz and Gmf for the Fd part of γG1 molecules, and Gma and non-a for the Fc part. Isolation of the γG1 fraction from the unusual sera demonstrated the presence of the important non-a antigen in the γG1 fraction. Through the use of immunoadsorbents it was shown that these antigens were not part of a single molecule but that separate molecules were involved. The accumulated evidence indicated that the appearance of such homoalleles on the same chromosome probably resulted from a recent gene duplication, giving rise to two γG1 cistrons on one chromosome.
Article|
May 01 1971
EVIDENCE FOR RECENT DUPLICATIONS AMONG CERTAIN GAMMA GLOBULIN HEAVY CHAIN GENES
J. B. Natvig,
J. B. Natvig
From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021
Search for other works by this author on:
T. E. Michaelsen,
T. E. Michaelsen
From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021
Search for other works by this author on:
H. G. Kunkel
H. G. Kunkel
From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021
Search for other works by this author on:
J. B. Natvig
From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021
T. E. Michaelsen
From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021
H. G. Kunkel
From the Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway, and The Rockefeller University, New York 10021
Received:
December 20 1970
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 133 (5): 1004–1014.
Article history
Received:
December 20 1970
Citation
J. B. Natvig, T. E. Michaelsen, H. G. Kunkel; EVIDENCE FOR RECENT DUPLICATIONS AMONG CERTAIN GAMMA GLOBULIN HEAVY CHAIN GENES . J Exp Med 1 May 1971; 133 (5): 1004–1014. doi: https://doi.org/10.1084/jem.133.5.1004
Download citation file: